The Misano racetrack was designed in 1969 (3,488 metres at the time) and opened in 1972.
To the side of the track there was only small open pit area and a building used exclusively by the racetrack offices.
Until 1993, it hosted the Italian GPs, alternating with the circuits of Monza, Imola and Mugello, while from 1985 to 1987 it hosted the San Marino GP.
In the early 1990s, it underwent renovations over various stages, to maintain the availability of the increasingly efficient facility.
In 1993, a serious accident at the Misano corner ended the career of American champion Wayne Rainey, who lost the use of his legs.
Fans had to wait until 2007 for the MotoGP to return to Romagna. The hamlet of Santamonica is now once again part of the MotoGP, thanks to important works that changed the direction of travel (from anti-clockwise to clockwise), lengthened the track (now 4,226 metres) and widened the roadway (which now measures 14 metres).
In 2012, the track was named after the unforgettable Marco Simoncelli.